The hypothesis that neutrophils play an important role in the pathogenesis of gastric ulceration induced by nonsteroidal anti-inflammatory drugs (NSAIDs) was tested in rats. Rats made neutropenic (i.e., had neutrophils (white blood cells) removed from their bloodstream) by prior treatment with an antibody to rat neutrophils were found to be significantly more resistant to the gastric-damaging actions of indomethacin or naproxen than were control rats or rats treated with serum that did not contain neutrophil antibodies. These results suggest an important role for neutrophils in the pathogenesis of NSAID-induced gastric ulceration. Neutrophils may be important in the vascular injury that occurs early after administration of these compounds.
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