This study explored the possibility that Antibe’s lead drug, ATB-346, would be effective in a murine model of hereditary intestinal cancer (APCMin+ mouse). Daily treatment with ATB-346 was significantly more effective at preventing intestinal polyp formation than naproxen. Significant beneficial effects were seen with a treatment period of only 3–7 days, and reversal of existing polyps was observed in the colon. ATB-346 may represent a promising agent for chemoprevention of tumorigenesis in the GI tract and elsewhere.


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