In vascular tissues, hydrogen sulphide (H2S) is mainly produced from L-cysteine by the cystathionine gamma-lyase (CSE) enzyme. Recent studies show that administration of H2S to endothelial cells in culture stimulates cell proliferation, migration and tube formation. Angiogenesis, the formation of new blood vessels, is crucial in the early stage of wound healing. Pharmacological modulation of H2S-mediated angiogenic pathways may open the door for novel therapeutic approaches.

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