The chemical versatility of sulfur and its abundance in the prebiotic Earth as reduced sulfide (H2S) implicate this molecule in the origin of life 3.8 billion years ago and also as a major source of energy in the first seven-eighths of evolution. This article provides an in-depth review of the origins of hydrogen sulfide’s physiological functions, also explaining its unique role as a signalling molecule and metabolic regulator, including its anti-inflammatory properties.


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