The endogenous metabolism and physiological functions of hydrogen sulfide (H2S) position this gas well in the novel family of endogenous gaseous transmitters, termed “gasotransmitters.” This positioning of H2S will open an exciting field—H2S physiology—encompassing realization of the interaction of H2S and other gasotransmitters, sulfurating modification of proteins, and the functional role of H2S in multiple systems. It may shed light on the pathogenesis of many diseases related to the abnormal metabolism of H2S.


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