New non-opioid pain medication: how is the biotech industry fighting pain after the opioid crisis?

February 26, 2024
By Willow Shah-Neville

Despite the market still being dominated by cheap opioid-based painkillers that are widely available, highly addictive, and firmly established, Vertex’s success in these trials has provided a reason to be hopeful. And it’s not just Vertex; other biotech companies are also attempting to develop new, non-addictive ways to fight pain.

View Full Article >
American Council on Science and Health

Antibe's Non-Opioid Pain Drug Otenaproxesul Looks Good in Phase IIb Trials

August 5, 2020
By Josh Bloom

In March I wrote about Phase IIa results of a novel NSAID-like drug ATB-346 (now called otenaproxesul), which is structurally and functionally similar to naproxen (Aleve). But the non-opioid drug lacks its gastrointestinal side effects, especially ulcers. Now Phase IIb results are in and it still looks good. Will it become the first member of a novel class of pain drugs? We could sure use it.

View Full Article >
Globalive Media

Powerful Pain Relief – Daniel Legault, Antibe Therapeutics

May 8, 2020
By Dan Legault

Millions of people rely on pain relief drugs on a daily basis, but these treatments can carry significant side effects. Antibe Therapeutics CEO Daniel Legault details to Anthony Lacavera the startup’s new anti-inflammatory drug that provides pain relief in a novel way without the health risks associated with typical treatments.

View Full Video >
American Council on Science and Health

Pain Relief And No Ulcers? 'Magic Aleve' In Clinical Trials

March 2, 2020
By Josh Bloom

Antibe Therapeutics, a Toronto-based pharmaceutical company, is evaluating an experimental drug in Phase II clinical trials that could be a much safer (and possibly more effective) option for the treatment of chronic pain and inflammation than anything we have now. And, although it is still too early to celebrate, the data so far isn’t simply good. It’s great.

View Full Article >
British Journal of Pharmacology

Hydrogen Sulfide in Biology & Medicine

February 16, 2020
By Andreas Papapetropoulos, John L. Wallace, Rui Wang

This issue of BJP highlights the substantial breadth of research related to H2S. Like NO and carbon monoxide, H2S plays very important roles in a wide range of physiological and pathophysiological processes. Moreover, significant progress has been made in recent years towards targeting H2S in drug design, with translation to human applications on the horizon.

View Full Article >

The Secret to a Safer NSAID: Hydrogen Sulfide Gas

June 14, 2019
By Candice Tang

If you’re experiencing a headache or pain in your joints, do you reach for an aspirin or Advil? These are common non-steroidal anti-inflammatory drugs or NSAIDs found in almost every home and are among the most widely used drugs in the world. But while they are effective painkillers, most people are unaware of their dangerous effects on the gastrointestinal (GI) tract.

View Full Article >
Nature Medicine

Smelly gas protects against clogged arteries

January 14, 2019
By Colin Barras

Hydrogen sulfide has a bad reputation, and deservedly so: not only does the gas smell of rotten eggs, but it is also so toxic that in large quantities it can cause respiratory failure and even death. But over the last 20 years, biologists have learned that the gas also helps keep the circulatory system functioning properly. Now physiologist Ingrid Fleming and her collaborators speculate that people with atherosclerosis might actually benefit from taking an oral supplement that generates hydrogen sulfide inside their bodies.

View Full Article >


This is an external link. Click “OK” to continue.