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Non-steroidal anti-inflammatory drugs (NSAIDs) are the main category of drugs used to treat disorders characterized by pain and inflammation, with nearly 100 million tablets administered daily in the United States alone. However, their use is constrained—and often contraindicated—by frequent bleeding and ulceration of the digestive tract. The need to improve the safety of NSAIDs has been amplified by the opioid crisis, prompting an urgent worldwide demand for safe, effective and non-addictive pain medications.
