Protecting the digestive tract is the key to developing safer, non-addictive therapeutics for pain and inflammation.
Today’s solutions to pain and inflammation
The main mechanism of NSAID-induced gastrointestinal damage was identified in 1990 by Dr. John L. Wallace, Antibe’s founder and Chief Scientific Officer. Several attempts have since been made to overcome this problem. These have included the development of selectively targeted NSAIDs, the use of enteric coatings, and co-administration of stomach acid reduction medications. None of these efforts have solved the gastrointestinal toxicity of NSAIDs, and some have resulted in increased risk to the digestive tract and other body systems. Even so, a longstanding lack of alternatives has led to continued growth in NSAID usage, ranging from day-to-day consumer use to the management of severe pain.
Hydrogen Sulfide and cellular function
In 2002, hydrogen sulfide was identified as one of three biologically important gases, now collectively termed “gasotransmitters”. Previously viewed as hostile to life, hydrogen sulfide—along with nitric oxide and carbon monoxide—have come to be recognized as central to a wide range of key cellular functions. In 2003, Dr. Wallace and his colleagues identified hydrogen sulfide’s anti-inflammatory properties. Over the succeeding years, their work would demonstrate hydrogen sulfide’s gastrointestinal-protective potential, leading to the design of Antibe’s drug platform.
* NicOx is the first company to develop and gain regulatory approval for gasotransmitter-based therapeutics.
*NicOx is the first company to develop gasotransmitter-based therapeutics.