Our Science

Transforming the treatment of pain and inflammation with breakthrough science

Our science leverages two crucial insights by Dr. John L. Wallace and his colleagues. The first identified the mechanism by which NSAIDs cause stomach ulcers and bleeding—radically altering the prevailing medical doctrine. A decade later, his discovery of hydrogen sulfide's anti-inflammatory potential led to the research project that became Antibe Therapeutics.

Today's solutions FOR ACUTE pain

The main mechanism of NSAID-induced gastrointestinal damage was identified in 1990 by Dr. Wallace and his colleagues. Several scientific and commercial attempts have since been made to overcome the problem. These have included the development of selectively targeted NSAIDs, the use of enteric coatings, and co-administration of stomach acid reduction medications. None of these efforts have solved the gastrointestinal toxicity of NSAIDs, and some have resulted in increased risk to the digestive tract and other body systems.

Hydrogen Sulfide and cellular function

In 2002, hydrogen sulfide was identified as one of three biologically important gases, now collectively termed gasotransmitters or gaseous mediators. Previously viewed as hostile to life, hydrogen sulfide—along with nitric oxide and carbon monoxide—have emerged as central to biology, important in a wide range of cellular functions. In 2003, Dr. Wallace and his colleagues began investigating hydrogen sulfide’s anti-inflammatory properties. Over the succeeding years, their work would demonstrate its GI-sparing potential, leading to the design of Antibe’s hydrogen sulfide platform.

Publications

Mar 2024

Assessment of the Pharmacokinetics and Safety of Otenaproxesul, a Non-Abusable, Novel Anti-Inflammatory /Analgesic Compound

STAUFFER ET AL., ASRA Pain Medicine Meeting (2024)

Mar 2024

A Phase 1B, 3-Dose Arm Study to Assess Pharmacokinetics and Safety of Otenaproxesul, a Non-Abusable, Novel Anti-Inflammatory Compound in Healthy Male and Female Subjects Under Fasting Conditions

STAUFFER ET AL., American Academy of Pain Medicine Meeting (2024)

Sep 2022

References

July 2023

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Transforming the treatment of pain and inflammation with breakthrough science

Today's solutions FOR ACUTE pain

Hydrogen Sulfide and cellular function

Publications

Assessment of the Pharmacokinetics and Safety of Otenaproxesul, a Non-Abusable, Novel Anti-Inflammatory /Analgesic Compound

A Phase 1B, 3-Dose Arm Study to Assess Pharmacokinetics and Safety of Otenaproxesul, a Non-Abusable, Novel Anti-Inflammatory Compound in Healthy Male and Female Subjects Under Fasting Conditions

POSTER: Potent Anti-Inflammatory Effects of Otenaproxesul, a Novel H2S-Releasing NSAID, in a Human Model of Inflammation

Potent Anti-Inflammatory Effects of Otenaproxesul, a Novel H2S-Releasing NSAID, in a Human Model of Inflammation

Gaseous Mediators as a Key Molecular Targets for the Development of Gastrointestinal-Safe Anti-Inflammatory Pharmacology

References

Proton pump inhibitors may enhance the risk of digestive diseases by regulating intestinal microbiota

H2S donor ameliorates paclitaxel-induced neuropathic pain in mice

Hydrogen Sulfide as Potential Regulatory Gasotransmitter in Arthritic Diseases